Rev Protein of Human Immunodeficiency Virus Type 1 Facilitates Translation of rev-dependent Viral Messenger RNAs.
نویسندگان
چکیده
منابع مشابه
Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein.
Rev, a major regulatory protein of human immunodeficiency virus type 1, has been demonstrated to shuttle between the nucleus and cytoplasm of infected cells. The fate of the Rev protein in living cells was evaluated by pulse-chase experiments using a transient Rev expression system. Sixteen hours after chasing with unlabelled amino acids, 45% of the labelled Rev was still present, which clearly...
متن کاملRestriction of human immunodeficiency virus type 1 Rev function in murine A9 cells involves the Rev C-terminal domain.
The human immunodeficiency virus type 1 (HIV-1) Rev and human T-cell leukemia virus type 1 (HTLV-1) Rex proteins are essential for the expression of viral structural proteins and productive infection. Both contain a nuclear export signal (NES) in their C-terminal domain and a nuclear localization signal (NLS) in their N-terminal domain. The NES and NLS are necessary for shuttling between nucleu...
متن کاملA novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1.
At the cellular level, cells infected with human immunodeficiency virus type 1 (HIV-1) exhibit immunity to a second infection by the virus that initiated the first infection or by related viruses [superinfection resistance (SIR)]. In the case of HIV infection, SIR was basically attributed to downregulation of the CD4 receptors. We have recently reported on an interaction between HIV-1 Rev and i...
متن کاملConserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.
Visna virus encodes a posttranscriptional regulatory protein that is functionally analogous to the Rev trans activator of human immunodeficiency virus type 1. Here, we demonstrate that the known functional organization of the human immunodeficiency virus type 1 Rev trans activator is shared by the distantly related visna virus Rev protein. In particular, both Rev proteins contain an N-terminal ...
متن کاملPhenotypic analysis of human immunodeficiency virus type 1 Rev trimerization-interface mutants in human cells.
Nuclear export of unspliced and incompletely spliced human immunodeficiency virus type 1 mRNA is mediated by the viral Rev protein. Rev binds to a structured RNA motif known as the Rev-response element (RRE), which is present in all Rev-dependent transcripts, and thereby promotes entry of the ribonucleoprotein complex into the nuclear-export pathway. Recent evidence indicates that a dimerizatio...
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ژورنال
عنوان ژورنال: ACTA HISTOCHEMICA ET CYTOCHEMICA
سال: 1997
ISSN: 0044-5991,1347-5800
DOI: 10.1267/ahc.30.617